Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 20/20 | 0.57 |
| ▸ | INSR | P06213 | 7/20 | 0.57 |
| ▸ | TXK | P42681 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3800898 | 0.94 | ITK (0.66) | ITKINSRTXK | |
| SCHEMBL19236089 | 0.93 | ITK (0.53) | ITKINSRTXK | |
| SCHEMBL3796215 | 0.92 | ITK (0.54) | ITKINSRTXK | |
| SCHEMBL3812178 | 0.91 | ITK (0.53) | ITKINSRTXK | |
| SCHEMBL3798557 | 0.87 | KDM4E (0.52) | ITKINSR | |
| SCHEMBL3799723 | 0.86 | MEN1 (0.51) | ITKINSR | |
| SCHEMBL13076398 | 0.86 | ITK (0.53) | ITKINSRTXK | |
| SCHEMBL3791183 | 0.85 | MEN1 (0.50) | ITKINSR | |
| SCHEMBL3800341 | 0.85 | ITK (0.48) | ITKINSRTXK | |
| SCHEMBL13077026 | 0.84 | MEN1 (0.53) | ITKINSRTXK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |