Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 8/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.49 |
| ▸ | KDR | P35968 | 6/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
| ▸ | ITK | Q08881 | 4/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3799723 | 0.89 | MEN1 (0.51) | MEN1KMT2AEGFRFGFR1KDR | |
| SCHEMBL19236089 | 0.86 | ITK (0.53) | MEN1KMT2AEGFRFGFR1KDR | |
| SCHEMBL13077039 | 0.85 | ITK (0.57) | ITKINSR | |
| SCHEMBL3796215 | 0.85 | ITK (0.54) | MEN1KMT2AEGFRFGFR1KDR | |
| SCHEMBL3800898 | 0.84 | ITK (0.66) | ITKINSR | |
| SCHEMBL3812178 | 0.82 | ITK (0.53) | IRAK4ITKINSR | |
| SCHEMBL3798557 | 0.81 | KDM4E (0.52) | MEN1KMT2AEGFRFGFR1KDR | |
| SCHEMBL13076398 | 0.79 | ITK (0.53) | MEN1KMT2AEGFRFGFR1KDR | |
| SCHEMBL3800341 | 0.79 | ITK (0.48) | MEN1KMT2AMAP3K7IRAK1IRAK4 | |
| SCHEMBL13077026 | 0.77 | MEN1 (0.53) | MEN1KMT2AEGFRFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |