SCHEMBL1307741

SCHEMBL1307741

N#CCn1ccnc1-c1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.54
PLAA Q9Y263 1/20 0.45
ALPG P10696 1/20 0.44
KDM4E B2RXH2 2/20 0.41
MEN1 O00255 1/20 0.41
POLB P06746 1/20 0.41
PKM P14618 1/20 0.41
KMT2A Q03164 1/20 0.41
LIMK2 P53671 1/20 0.40
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA3 P07451 1/20 0.38
CA4 P22748 1/20 0.38
CA6 P23280 1/20 0.38
CA5A P35218 1/20 0.38
CA7 P43166 1/20 0.38
CA9 Q16790 1/20 0.38
CA13 Q8N1Q1 1/20 0.38
CA14 Q9ULX7 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9783800 0.84 ESR1 (0.44) ESR1PLAAALPGKDM4EMEN1
SCHEMBL63262 0.83 ESR1 (0.59) ESR1PLAAALPGKDM4ELIMK2
SCHEMBL31398143 0.82 MAP4K4 (0.39) ESR1PLAAKDM4EMEN1POLB
SCHEMBL15956713 0.81 ESR1 (0.56) ESR1PLAAALPGBRD4PDE6D
SCHEMBL5321444 0.80 ESR1 (0.62) ESR1PLAAALPGKDM4EKMT2A
SCHEMBL9783865 0.78 LRRK2 (0.43) ESR1PLAAKDM4EKDR
SCHEMBL7095574 0.77 ESR1 (0.68) ESR1PLAAALPGPOLBKMT2A
SCHEMBL27850097 0.77 ESR1 (0.58) ESR1PLAAALPGKDM4EKMT2A
SCHEMBL2793396 0.77 ESR1 (0.58) ESR1PLAAALPGKDM4EKMT2A
SCHEMBL27452733 0.77 ESR1 (0.63) ESR1PLAAALPGLIMK2CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023136203-A1 RESIN COMPOSITION, FILM, AND DISPLAY DEVICE 住友化学株式会社 2023-07-20 WO disclosed
WO-2023112650-A1 METHOD FOR MANUFACTURING LENS 住友化学株式会社 2023-06-22 WO disclosed
WO-2022210268-A1 RESIN COMPOSITION, FILM, AND COPOLYMER 住友化学株式会社 2022-10-06 WO disclosed
WO-2019156326-A1 SOLVENT-FREE COATING COMPOSITION 주식회사 케이씨씨 2019-08-15 WO disclosed
CN-103116244-B Hardening resin composition 住友化学株式会社 2018-11-13 CN disclosed
CN-107434941-A Resin combination and cured film 住友化学株式会社 2017-12-05 CN disclosed
CN-102807778-B Hardening resin composition 住友化学株式会社 2017-11-07 CN disclosed
CN-107272331-A Hardening resin composition and cured film 住友化学株式会社 2017-10-20 CN disclosed
CN-102809897-B Hardening resin composition 住友化学株式会社 2017-03-01 CN disclosed
CN-105372937-A Photosensitive resin composition SUMITOMO CHEMICAL CO 2016-03-02 CN disclosed
CN-103113805-A Curable resin composition SUMITOMO CHEMICAL CO 2013-05-22 CN disclosed
CN-103116244-A Curable resin composition SUMITOMO CHEMICAL CO 2013-05-22 CN disclosed
CN-103048881-A Curable resin composition SUMITOMO CHEMICAL CO 2013-04-17 CN disclosed
CN-102807778-A Curable resin composition SUMITOMO CHEMICAL CO 2012-12-05 CN disclosed
CN-102809897-A Curable resin composition SUMITOMO CHEMICAL CORP 2012-12-05 CN disclosed
US-8053457-B2 3-imidazolyl-indoles for the treatment of proliferative diseases NOVARTIS AG (CH) 2011-11-08 US disclosed
US-20100125064-A1 3-Imidazolyl-Indoles for the Treatment of Proliferative Diseases NOVARTIS AG (CH) 2010-05-20 US disclosed
EP-2142535-A2 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES Novartis Ag (CH) 2010-01-13 EP disclosed
WO-2008119741-A2 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES NOVARTIS AG (CH) 2008-10-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100125064-A1 3-Imidazolyl-Indoles for the Treatment of Proliferative Diseases MDM4, TP53, MDM2 ESR1 908/4885PLAA 4141/4885ALPG 4269/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.