Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.31 |
| ▸ | HTR2A | P28223 | 3/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | TLR2 | O60603 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13077711 | 0.88 | ADRB2 (0.52) | ADRB2ADRB1ADRB3MEN1LMNA | |
| SCHEMBL14571120 | 0.87 | ADRB2 (0.40) | ADRB2ADRB1ADRB3MEN1LMNA | |
| SCHEMBL13077708 | 0.87 | ADRB2 (0.43) | ADRB2ADRB1ADRB3MEN1LMNA | |
| SCHEMBL13077704 | 0.84 | ADRB2 (0.57) | ADRB2ADRB1ADRB3MEN1LMNA | |
| SCHEMBL13077529 | 0.84 | NPY1R (0.39) | ADRB2ADRB1ADRB3CYP2D6HTR2A | |
| SCHEMBL13077544 | 0.83 | ADRB2 (0.45) | ADRB2ADRB1LMNAALDH1A1CYP2D6 | |
| SCHEMBL13077712 | 0.79 | ADRB2 (0.46) | ADRB2ADRB1ADRB3MEN1LMNA | |
| SCHEMBL13077710 | 0.78 | ADRB2 (0.53) | ADRB2ADRB1ADRB3MEN1LMNA | |
| SCHEMBL13040058 | 0.76 | ADRB2 (0.41) | ADRB2ADRB1ADRB3MEN1LMNA | |
| SCHEMBL13077340 | 0.73 | NR2E1 (0.39) | ADRB2ADRB1ADRB3LMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825263-B2 | Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive | NICOX S.A. (FR) | 2010-11-02 | — | — | US | disclosed |