Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879899 | 0.74 | MEN1 (0.44) | MEN1KMT2ATSHRPOLB | |
| SCHEMBL31135583 | 0.63 | KDM4E (0.54) | MEN1KMT2AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL6264028 | 0.62 | NPSR1 (0.45) | ALDH1A1TSHRSMN1; SMN2POLB | |
| SCHEMBL6247449 | 0.62 | CYP3A4 (0.49) | ALDH1A1TSHRSMN1; SMN2POLB | |
| SCHEMBL25724068 | 0.61 | MEN1 (0.54) | MEN1KMT2AADORA3ADORA2BHDAC1 | |
| SCHEMBL24031128 | 0.61 | HDAC1 (0.78) | ALDH1A1POLBHDAC1HDAC11HDAC8 | |
| SCHEMBL6274097 | 0.61 | CYP3A4 (0.58) | MEN1KMT2AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL6242827 | 0.61 | MEN1 (0.36) | MEN1KMT2AALDH1A1SMN1; SMN2HDAC1 | |
| SCHEMBL7889268 | 0.61 | TSHR (0.44) | TSHRLMNAHTTPOLB | |
| SCHEMBL22745712 | 0.60 | HDAC1 (0.48) | MEN1KMT2AALDH1A1HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100278835-A1 | NOVEL COMPOUNDS 660 | ASTRAZENECA UK LIMITED (GB) | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100278835-A1 | NOVEL COMPOUNDS 660 | RB1, RPP30, SARS1 | MEN1 1527/4885KMT2A 4545/4885ALDH1A1 2596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.