⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12442495 | 1.00 | — | — | |
| SCHEMBL12050298 | 1.00 | — | — | |
| SCHEMBL6408429 | 0.76 | — | — | |
| SCHEMBL22421543 | 0.74 | TSHR (0.32) | — | |
| SCHEMBL17151557 | 0.73 | — | — | |
| SCHEMBL17148514 | 0.73 | ALDH1A1 (0.33) | — | |
| SCHEMBL5164866 | 0.73 | — | — | |
| SCHEMBL20940034 | 0.71 | — | — | |
| SCHEMBL45302 | 0.71 | — | — | |
| SCHEMBL13103861 | 0.71 | TSHR (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11673892-B2 | Bicyclic compounds for use as RIP1 kinase inhibitors | GENENTECH, INC. (US) | 2023-06-13 | — | — | US | disclosed |
| US-11673892-B2 | Bicyclic compounds for use as RIP1 kinase inhibitors | GENENTECH, INC. (US) | 2023-06-13 | — | — | US | disclosed |
| US-20200283446-A1 | BICYCLIC COMPOUNDS FOR USE AS RIP1 KINASE INHIBITORS | GENENTECH, INC. (US) | 2020-09-10 | — | — | US | disclosed |