Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | CASP1 | P29466 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1623478 | 0.80 | MEN1 (0.44) | ALDH1A1GAACASP1MEN1KMT2A | |
| SCHEMBL12721185 | 0.76 | MEN1 (0.45) | ALDH1A1GAACASP1MEN1KMT2A | |
| SCHEMBL13080249 | 0.66 | KMT2A (0.47) | ALDH1A1GAAMEN1KMT2AMAPT | |
| SCHEMBL1621925 | 0.66 | ALDH1A1 (0.42) | ALDH1A1GAACASP1MEN1KMT2A | |
| SCHEMBL12723274 | 0.65 | MEN1 (0.43) | ALDH1A1GAACASP1MEN1KMT2A | |
| SCHEMBL12721492 | 0.65 | MEN1 (0.43) | ALDH1A1GAACASP1MEN1KMT2A | |
| SCHEMBL10150332 | 0.64 | GAA (0.50) | ALDH1A1GAACASP1MEN1KMT2A | |
| SCHEMBL10150308 | 0.64 | GAA (0.50) | ALDH1A1GAACASP1MEN1KMT2A | |
| SCHEMBL13080560 | 0.64 | CHEK2 (0.42) | ALDH1A1GAACASP1MEN1KMT2A | |
| SCHEMBL12721443 | 0.64 | CHEK2 (0.42) | ALDH1A1GAACASP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8283354-B2 | Voltage gated sodium and calcium channel inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-09 | — | — | US | disclosed |
| US-8283354-B2 | Voltage gated sodium and calcium channel inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-09 | — | — | US | disclosed |