Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 2/20 | 0.46 |
| ▸ | GBA1 | P04062 | 4/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | STAT6 | P42226 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13080699 | 0.91 | GBA1 (0.47) | ACP1GBA1HDAC3MTORHDAC1 | |
| SCHEMBL13080784 | 0.91 | GBA1 (0.47) | ACP1GBA1HDAC3MTORHDAC1 | |
| SCHEMBL13080669 | 0.91 | ACP1 (0.57) | ACP1GBA1ABCG2KDM4ETSHR | |
| SCHEMBL13080736 | 0.91 | ACP1 (0.57) | ACP1GBA1ABCG2KDM4ETSHR | |
| SCHEMBL1623541 | 0.89 | SMAD3 (0.52) | GBA1HDAC3MTORHDAC1HDAC2 | |
| SCHEMBL1623546 | 0.89 | SMAD3 (0.52) | GBA1HDAC3MTORHDAC1HDAC2 | |
| SCHEMBL1624126 | 0.86 | HDAC3 (0.40) | HDAC3MTORHDAC1HDAC2HDAC6 | |
| SCHEMBL1624132 | 0.86 | HDAC3 (0.40) | HDAC3MTORHDAC1HDAC2HDAC6 | |
| SCHEMBL13080698 | 0.86 | MEN1 (0.46) | ACP1GBA1ABCG2KDM4ESTAT6 | |
| SCHEMBL13080697 | 0.83 | CYP1A2 (0.49) | ACP1GBA1ABCG2KDM4ESTAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8283354-B2 | Voltage gated sodium and calcium channel inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-09 | — | — | US | disclosed |