Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 5/20 | 0.47 |
| ▸ | ACP1 | P24666 | 2/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | STAT6 | P42226 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13080699 | 1.00 | GBA1 (0.47) | GBA1ACP1ABCG2MAPTKDM4E | |
| SCHEMBL13080682 | 0.91 | ACP1 (0.46) | GBA1ACP1ABCG2MAPTKDM4E | |
| SCHEMBL13080685 | 0.90 | GBA1 (0.48) | GBA1ACP1ABCG2MAPTKDM4E | |
| SCHEMBL13080689 | 0.90 | MAPT (0.47) | GBA1ABCG2MAPTKDM4ESTAT6 | |
| SCHEMBL13080736 | 0.90 | ACP1 (0.57) | GBA1ACP1ABCG2MAPTKDM4E | |
| SCHEMBL13080669 | 0.90 | ACP1 (0.57) | GBA1ACP1ABCG2MAPTKDM4E | |
| SCHEMBL13080706 | 0.89 | CYP1A2 (0.48) | GBA1MAPTTSHRMEN1KMT2A | |
| SCHEMBL13080708 | 0.89 | GBA1 (0.47) | GBA1ACP1ABCG2MAPTKDM4E | |
| SCHEMBL13080688 | 0.89 | GBA1 (0.47) | GBA1ACP1ABCG2MAPTKDM4E | |
| SCHEMBL1621278 | 0.88 | MEN1 (0.49) | GBA1MAPTKDM4ENPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8283354-B2 | Voltage gated sodium and calcium channel inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-09 | — | — | US | disclosed |