Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ACP1 | P24666 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | GBA1 | P04062 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13080756 | 0.91 | TSHR (0.57) | TSHRTP53MAPTKDM4EACP1 | |
| SCHEMBL13080744 | 0.91 | TSHR (0.48) | TSHRTP53MAPTKDM4EACP1 | |
| SCHEMBL13080745 | 0.89 | TSHR (0.61) | TSHRTP53MAPTKDM4EACP1 | |
| SCHEMBL1621972 | 0.89 | SMAD3 (0.56) | TSHRTP53MAPTKDM4ELMNA | |
| SCHEMBL13080749 | 0.85 | TSHR (0.57) | TSHRTP53MAPTKDM4EACP1 | |
| SCHEMBL13080770 | 0.82 | TSHR (0.47) | TSHRTP53MAPTKDM4EACP1 | |
| SCHEMBL13080748 | 0.82 | TSHR (0.58) | TSHRTP53MAPTKDM4EACP1 | |
| SCHEMBL13080754 | 0.80 | TSHR (0.56) | TSHRTP53MAPTKDM4EACP1 | |
| SCHEMBL13080676 | 0.80 | ABCG2 (0.57) | TSHRMAPTKDM4EACP1LMNA | |
| SCHEMBL1624722 | 0.80 | SMAD3 (0.55) | TSHRTP53MAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8283354-B2 | Voltage gated sodium and calcium channel inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-09 | — | — | US | disclosed |