SCHEMBL13085387

SCHEMBL13085387

Cc1cc(Br)cc(C(N)=O)c1NC(=O)c1cc(Cn2nnnc2C(F)(F)F)nn1-c1ncccc1C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPK13 O15264 1/20 0.35
MAPK12 P53778 1/20 0.35
MAPK11 Q15759 1/20 0.35
MAPK14 Q16539 1/20 0.35
NTRK1 P04629 6/20 0.33
SLC2A1 P11166 5/20 0.33
SLC2A3 P11169 5/20 0.33
SLC2A4 P14672 5/20 0.33
SLC2A2 P11168 3/20 0.33
CD38 P28907 1/20 0.33
PPARG P37231 1/20 0.32
P2RX7 Q99572 1/20 0.31
C5AR1 P21730 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13085589 0.94 SLC2A1 (0.33) NTRK1SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL13085388 0.92 GAA (0.34) MAPK13MAPK12MAPK11MAPK14NTRK1
SCHEMBL13085386 0.92 MAPK13 (0.34) MAPK13MAPK12MAPK11MAPK14NTRK1
SCHEMBL13085462 0.92 MAPK13 (0.36) MAPK13MAPK12MAPK11MAPK14NTRK1
SCHEMBL13085389 0.91 MAPK13 (0.34) MAPK13MAPK12MAPK11MAPK14NTRK1
SCHEMBL13085382 0.90 MAPK13 (0.33) MAPK13MAPK12MAPK11MAPK14NTRK1
SCHEMBL13085483 0.87 SLC2A1 (0.34) NTRK1SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL13085608 0.87 SLC2A1 (0.32) SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL13085270 0.86 MAPK14 (0.34) MAPK13MAPK12MAPK11MAPK14NTRK1
SCHEMBL13085624 0.85 SLC2A1 (0.30) SLC2A1SLC2A3SLC2A4SLC2A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8324390-B2 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2012-12-04 US disclosed
US-8324390-B2 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2012-12-04 US disclosed
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2010-10-07 US disclosed
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2010-10-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides ANTXR2, PNISR, H1-5 MAPK13 4357/4885MAPK12 3656/4885MAPK11 3780/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.