PNISR — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to PNISR by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
L-Arginine Role for Stone Lower Ureter : A Randomized Control Study	PHASE4	COMPLETED
L-Arginine in Pre-Eclampsia	PHASE3	COMPLETED
Nutrition Therapy in Improving Immune System in Patients With Bladder Cancer That Can Be Removed by Surgery	PHASE3	ACTIVE_NOT_RECRUITING
Effect of Arginine- and Glutamine-based Oral Formulations on Salivary Biomarkers and Clinical Severity of Radiation-induced Oral Mucositis in Head and Neck Cancer: A Randomized Controlled Trial	PHASE2	COMPLETED
Cixutumumab and Temsirolimus in Treating Patients With Metastatic Prostate Cancer	PHASE1/PHASE2	COMPLETED
Intravenous L-Citrulline Influence on the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failure in Patients With COVID-19	PHASE2	COMPLETED
Veliparib (ABT-888), an Oral PARP Inhibitor, and VX-970, an ATR Inhibitor, in Combination With Cisplatin in People With Refractory Solid Tumors	PHASE1	COMPLETED
iNOS With Positron Emission Tomography (PET) in Cellular Inflammation.	EARLY_PHASE1	COMPLETED
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients	nan	COMPLETED
Effect of Dietary Amino Acid Profile on Lipoprotein Metabolism, Vascular Reactivity and Inflammatory Markers	nan	COMPLETED
L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE)	nan	RECRUITING
Effect of Arginine and Glutamine on Radiation-induced Oral Mucositis: a Trible Blinded Randomized Controlled Clinical Trial	nan	COMPLETED
Clinical and Basic Research on the Necessity of Scar Tissue Resection During Intrauterine Adhesions	nan	UNKNOWN
Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein	nan	RECRUITING
Inhibition of SENP1 for the Suppression of OS Growth and Metastasis	nan	UNKNOWN
Role of Nitric Oxide in Malaria	nan	COMPLETED
Detection of EGFR Mutation in Malignant Pleural Effusion of Lung Cancer Patients and Cancer Cell Lines Establishment	nan	UNKNOWN
C1q/TNF-related Protein 9 (CTRP 9) Level in Preeclamptic Obese and Non-obese Pregnancies	nan	COMPLETED
Arginine Metabolism in Youth With Type 2 Diabetes	nan	RECRUITING
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD	nan	UNKNOWN
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms	nan	COMPLETED
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients	nan	RECRUITING
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD	nan	COMPLETED
Study of Arginine and Nitric Oxide in Patients With Diabetes	nan	COMPLETED
Study of the Articular Microbiota in Rheumatoid Arthritis.	nan	COMPLETED
Study of Heat Shock Proteins as Prognostic Factor of Acute Renal Failure in Children (HSP-Study)	nan	UNKNOWN
Rheo-Erythrocrine Dysfunction as a Biomarker for RIC Treatment in Acute Ischemic Stroke	nan	COMPLETED
Arginine Feeding: a Novel Strategy to Improve Protein Metabolism in Cancer and the Response to Surgery	nan	COMPLETED
MOLECULAR REGULATION OF MUSCLE GLUCOSE METABOLISM (AIMS 2A, 2B, 3)	nan	UNKNOWN
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PNISR binder may also engage these)

Protein	Name	Similarity
A2AJT4	—	1.000	A2AJT4 →
Q9JKL7	—	0.987	Q9JKL7 →
RBM26	RNA-binding protein 26	0.983	landscape →
Q8CFC7	—	0.982	Q8CFC7 →
D3ZTQ1	—	0.982	D3ZTQ1 →
Q8N2M8	—	0.981	Q8N2M8 →
Q53F19	—	0.981	Q53F19 →
A0JNI5	—	0.981	A0JNI5 →
Q5HZB6	—	0.981	Q5HZB6 →
BCLAF1	Bcl-2-associated transcription factor 1	0.981	landscape →
Q568R1	—	0.981	Q568R1 →
Q6NZN0	—	0.980	Q6NZN0 →
Q9P2N5	—	0.980	Q9P2N5 →
Q5ZM19	—	0.980	Q5ZM19 →
Q3USH5	—	0.980	Q3USH5 →
Q8K019	—	0.980	Q8K019 →
PNN	Pinin	0.979	landscape →
Q2T9I5	—	0.978	Q2T9I5 →
Q8BZR9	—	0.978	Q8BZR9 →
THRAP3	Thyroid hormone receptor-associated protein 3	0.978	landscape →
Q8QG78	—	0.978	Q8QG78 →
Q4KKX4	—	0.978	Q4KKX4 →
Q62415	—	0.977	Q62415 →
Q12872	—	0.976	Q12872 →
Q8BZX4	—	0.976	Q8BZX4 →
Q9UPT8	—	0.976	Q9UPT8 →
Q5SFM8	—	0.976	Q5SFM8 →
Q9NRA8	—	0.976	Q9NRA8 →
Q9HAU0	—	0.975	Q9HAU0 →
Q3UQU0	—	0.975	Q3UQU0 →