Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13086575 | 1.00 | BRD4 (0.35) | BRD4TP53MAPTSYKSMN1; SMN2 | |
| SCHEMBL2602011 | 0.87 | BRD4 (0.39) | BRD4HDAC1 | |
| SCHEMBL2602010 | 0.87 | BRD4 (0.39) | BRD4HDAC1 | |
| SCHEMBL2119736 | 0.82 | BRD4 (0.38) | BRD4TP53 | |
| SCHEMBL2117832 | 0.82 | BRD4 (0.38) | BRD4TP53 | |
| SCHEMBL607123 | 0.74 | BRD4 (0.47) | BRD4TP53SMN1; SMN2HDAC1 | |
| SCHEMBL2119892 | 0.73 | BRD4 (0.43) | BRD4HDAC1HDAC3HDAC8HDAC6 | |
| SCHEMBL13086307 | 0.73 | CCKBR (0.39) | — | |
| SCHEMBL13086285 | 0.73 | CCKBR (0.39) | — | |
| SCHEMBL2602023 | 0.73 | BRD4 (0.40) | BRD4TP53HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010121164-A2 | 1,4-BENZODIAZEPINONE COMPOUNDS AND THEIR USE IN TREATING CANCER | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-10-21 | — | — | WO | disclosed |