Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | THRB | P10828 | 1/20 | 0.73 |
| ▸ | HPGD | P15428 | 1/20 | 0.73 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.73 |
| ▸ | SNCA | P37840 | 1/20 | 0.73 |
| ▸ | RECQL | P46063 | 1/20 | 0.73 |
| ▸ | BLM | P54132 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | SLC7A11 | Q9UPY5 | 5/20 | 0.63 |
| ▸ | SENP2 | Q9HC62 | 4/20 | 0.63 |
| ▸ | SENP1 | Q9P0U3 | 4/20 | 0.63 |
| ▸ | SUMO2 | P61956 | 3/20 | 0.63 |
| ▸ | SUMO1 | P63165 | 3/20 | 0.63 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.63 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.56 |
| ▸ | GLB1 | P16278 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12534464 | 1.00 | APP (0.73) | APPMEN1ALDH1A1MAPTTHRB | |
| SCHEMBL12534467 | 0.87 | SENP2 (0.60) | APPMEN1ALDH1A1MAPTTHRB | |
| SCHEMBL12534470 | 0.86 | APP (0.54) | APPMEN1ALDH1A1MAPTTHRB | |
| Congo Red Free Acid SCHEMBL2583894 | 0.86 | APP (1.00) | APPMEN1ALDH1A1MAPTTHRB | |
| Congo Red Free Acid SCHEMBL29825625 | 0.86 | APP (1.00) | APPMEN1ALDH1A1MAPTTHRB | |
| Congo Red Free Acid SCHEMBL1254806 | 0.86 | APP (1.00) | APPMEN1ALDH1A1MAPTTHRB | |
| Congo Red Free Acid SCHEMBL29350758 | 0.86 | APP (1.00) | APPMEN1ALDH1A1MAPTTHRB | |
| SCHEMBL12534465 | 0.85 | PHLPP2 (0.54) | APPMEN1ALDH1A1MAPTTHRB | |
| Congo Red Free Acid SCHEMBL17272057 | 0.84 | APP (0.97) | APPMEN1ALDH1A1MAPTTHRB | |
| Congo Red Free Acid SCHEMBL326268 | 0.84 | APP (0.97) | APPMEN1ALDH1A1MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497260-B2 | 2-arylbenzothiophene derivatives or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition for the diagnosis or treatment of degenerative brain disease containing the same as active ingredient | Industry-University Cooperation Foundation Sogang University (KR) | 2013-07-30 | — | — | US | disclosed |
| US-20100261727-A1 | 2-ARYLBENZOTHIOPHENE DERIVATIVES OR PHARCEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARCEUTICAL COMPOSITION FOR THE DIAGNOSIS OR TREATMENT OF DEGENERATIVE BRAIN DISEASE CONTAINING THE SAME AS ACTIVE INGREDIENT | Industry-University Cooperation Foundation Sogang University | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261727-A1 | 2-ARYLBENZOTHIOPHENE DERIVATIVES OR PHARCEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARCEUTICAL COMPOSITION FOR THE DIAGNOSIS OR TREATMENT OF DEGENERATIVE BRAIN DISEASE CONTAINING THE SAME AS ACTIVE INGREDIENT | APP, PSEN1, PSEN2 | APP 1/4885MEN1 3443/4885ALDH1A1 3155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.