Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 14/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.55 |
| ▸ | DRD2 | P14416 | 11/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL378256 | 1.00 | DRD3 (0.55) | DRD3KCNH2DRD2CYP1A2 | |
| SCHEMBL14606013 | 0.87 | DRD3 (0.55) | DRD3KCNH2DRD2CYP1A2 | |
| SCHEMBL10107827 | 0.87 | DRD3 (0.57) | DRD3KCNH2DRD2CYP1A2 | |
| SCHEMBL919354 | 0.87 | DRD3 (0.55) | DRD3KCNH2DRD2CYP1A2 | |
| SCHEMBL6003533 | 0.84 | DRD3 (0.54) | DRD3KCNH2DRD2CYP1A2 | |
| SCHEMBL13007625 | 0.84 | DRD3 (0.55) | DRD3KCNH2DRD2CYP1A2 | |
| SCHEMBL3623998 | 0.83 | DRD3 (0.45) | DRD3KCNH2DRD2CYP1A2 | |
| SCHEMBL4666895 | 0.83 | DRD3 (0.45) | DRD3KCNH2DRD2CYP1A2 | |
| SCHEMBL3555050 | 0.83 | DRD3 (0.45) | DRD3KCNH2DRD2CYP1A2 | |
| SCHEMBL13312904 | 0.83 | DRD3 (0.45) | DRD3KCNH2DRD2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891057-B1 | AZABICYCLO[3.1.0]HEXANE DERIVAIVES AS DOPAMIN D3 RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2010-10-27 | — | — | EP | disclosed |
| EP-1891056-B1 | NOVEL COMPOUNDS | GLAXO GROUP LTD (GB) | 2010-10-13 | — | — | EP | disclosed |
| EP-2070922-A1 | Azabicyclo(3.1.0) hexane derivatives useful as modulators of dopamine D3 receptors | GLAXO GROUP LIMITED (GB) | 2009-06-17 | — | — | EP | disclosed |
| EP-1926723-B1 | AZABICYCLO (3,1,0) HEXAN DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE D3 RCEPTORS | GLAXO GROUP LTD (GB) | 2009-05-13 | — | — | EP | disclosed |
| WO-2009043883-A1 | AZABICYCLO [3. 1. O] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |
| WO-2007113232-A1 | AZABICYCLO [3. 1. 0] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2007-10-11 | — | — | WO | disclosed |
| WO-2007022934-A2 | AZABICYCLO (3, 1, 0) HEXAN DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2007-03-01 | — | — | WO | disclosed |