Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13089099 | 0.84 | AURKA (0.41) | ALDH1A1MAPTNPC1RAB9ACNR1 | |
| SCHEMBL12717314 | 0.72 | SMN1; SMN2 (0.64) | ALDH1A1MAPTNPC1NFKB1RAB9A | |
| SCHEMBL21427687 | 0.67 | AURKA (0.37) | AURKARPS6KB1 | |
| SCHEMBL31247297 | 0.66 | KDM4E (0.42) | KDM4EF13A1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL17689390 | 0.65 | CYP1A2 (0.53) | KDM4EF13A1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL20182048 | 0.64 | — | — | |
| SCHEMBL1010214 | 0.64 | MTNR1A (0.61) | MAPTNPC1RAB9ALMNABLM | |
| SCHEMBL6707038 | 0.63 | KDM4E (0.50) | KDM4EF13A1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1008891 | 0.62 | KDM4E (0.70) | KDM4EF13A1ALDH1A1MAPTNPC1 | |
| SCHEMBL31579654 | 0.62 | CNR1 (0.57) | KDM4EF13A1ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120943-A1 | NAPHTHALENE-BASED INHIBITORS OF ANTI-APOPTOTIC PROTEINS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2010-10-21 | — | — | WO | disclosed |