Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.66 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3062465 | 0.90 | MET (0.64) | METIRAK4HDAC1IRAK1 | |
| SCHEMBL4130448 | 0.88 | MET (0.69) | METHDAC1 | |
| SCHEMBL3067317 | 0.88 | MET (0.61) | METIRAK4HDAC1IRAK1 | |
| SCHEMBL1950688 | 0.87 | MET (0.71) | METIRAK4 | |
| SCHEMBL1952612 | 0.87 | MET (0.60) | METIRAK4HDAC1IRAK1 | |
| SCHEMBL1302552 | 0.87 | MET (0.64) | METHDAC1 | |
| SCHEMBL3062334 | 0.86 | MET (0.59) | METIRAK4HDAC1IRAK1 | |
| SCHEMBL1302876 | 0.86 | MET (0.59) | METIRAK4HDAC1IRAK1 | |
| SCHEMBL1301755 | 0.85 | MET (0.62) | METIRAK4HDAC1IRAK1 | |
| SCHEMBL13089762 | 0.83 | MET (0.56) | METIRAK4HDAC1IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8435981-B2 | 2-(heterocyclylbenzyl)pyridazinone derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-05-07 | — | — | US | disclosed |
| US-20100261697-A1 | 2-(HETEROCYCLYLBENZYL)PYRIDAZINONE DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 2010-10-14 | — | — | US | disclosed |
| US-20100261697-A1 | 2-(HETEROCYCLYLBENZYL)PYRIDAZINONE DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261697-A1 | 2-(HETEROCYCLYLBENZYL)PYRIDAZINONE DERIVATIVES | MET, RET, ERBB2 | MET 1/4885IRAK4 827/4885HDAC1 745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.