Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21483647 | 0.84 | PDE3B (0.53) | TSHRNPSR1PDE3BPDE3AALDH1A1 | |
| SCHEMBL7349339 | 0.81 | PDE3B (0.49) | TSHRPDE3BPDE3AALDH1A1MEN1 | |
| SCHEMBL10130351 | 0.80 | TSHR (0.58) | TSHRNPSR1PDE3BPDE3AALDH1A1 | |
| SCHEMBL10130347 | 0.80 | TSHR (0.58) | TSHRNPSR1PDE3BPDE3AALDH1A1 | |
| SCHEMBL10129864 | 0.80 | TSHR (0.58) | TSHRNPSR1PDE3BPDE3AALDH1A1 | |
| SCHEMBL13091164 | 0.76 | TSHR (0.69) | TSHRNPSR1ALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL29348226 | 0.75 | PDE3B (0.47) | TSHRNPSR1PDE3BPDE3AALDH1A1 | |
| SCHEMBL29348279 | 0.75 | PDE3B (0.47) | TSHRNPSR1PDE3BPDE3AALDH1A1 | |
| SCHEMBL13091216 | 0.74 | TSHR (0.66) | TSHRNPSR1ALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL7348345 | 0.73 | PDE3B (0.44) | TSHRNPSR1PDE3BPDE3AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010123139-A1 | ARYLCARBOXAMIDE DERIVATIVE HAVING SULFAMOYL GROUP | 持田製薬株式会社 (JP) | 2010-10-28 | — | — | WO | disclosed |