Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.57 |
| ▸ | FLT3 | P36888 | 8/20 | 0.57 |
| ▸ | KIT | P10721 | 7/20 | 0.57 |
| ▸ | CSF1R | P07333 | 5/20 | 0.57 |
| ▸ | FLT1 | P17948 | 5/20 | 0.57 |
| ▸ | FLT4 | P35916 | 5/20 | 0.57 |
| ▸ | LYN | P07948 | 4/20 | 0.57 |
| ▸ | BLK | P51451 | 4/20 | 0.57 |
| ▸ | LCK | P06239 | 3/20 | 0.57 |
| ▸ | AURKA | O14965 | 3/20 | 0.57 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.57 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.57 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.57 |
| ▸ | RET | P07949 | 3/20 | 0.57 |
| ▸ | MET | P08581 | 3/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.57 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.57 |
| ▸ | AXL | P30530 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3848792 | 0.89 | KDR (0.70) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL13097009 | 0.86 | LCLAT1 (0.49) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL12322989 | 0.84 | KDR (0.60) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL1499160 | 0.83 | KDR (0.58) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL4232674 | 0.81 | KDR (0.82) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL13096661 | 0.81 | NTRK1 (0.61) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL13873380 | 0.80 | KDR (0.68) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL3847135 | 0.79 | KIT (0.57) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL3845215 | 0.79 | KDR (0.66) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL3845211 | 0.78 | KDR (0.58) | KDRFLT3KITCSF1RFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261730-A1 | ALKYNYLARYL COMPOUNDS AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261730-A1 | ALKYNYLARYL COMPOUNDS AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | ALK, ALKBH3, EDNRB | KDR 6/4885FLT3 409/4885KIT 333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.