Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1309098 | 0.98 | CYP3A4 (0.40) | SIGMAR1CYP3A4TSHRCHRM5CHRM3 | |
| SCHEMBL1308768 | 0.87 | CYP3A4 (0.38) | SIGMAR1CYP3A4TSHRCHRM5CHRM3 | |
| Tert-Butyl Formate SCHEMBL27840516 | 0.85 | CYP3A4 (0.34) | SIGMAR1CYP3A4TSHRCHRM5CHRM3 | |
| SCHEMBL14085899 | 0.79 | CYP2D6 (0.43) | SIGMAR1CYP3A4TSHRCHRM5CHRM3 | |
| SCHEMBL1311224 | 0.79 | CYP3A4 (0.52) | SIGMAR1CYP3A4TSHRCHRM5CHRM3 | |
| SCHEMBL3097412 | 0.78 | EPHX1 (0.41) | SIGMAR1CYP3A4TSHRCHRM5CHRM3 | |
| Hydrochloric Acid SCHEMBL5729678 | 0.78 | CYP3A4 (0.53) | SIGMAR1CYP3A4TSHRCHRM5CHRM3 | |
| Hydrochloric Acid SCHEMBL6624641 | 0.77 | EPHX1 (0.40) | SIGMAR1CYP3A4TSHRCHRM5CHRM3 | |
| SCHEMBL476374 | 0.77 | KMT2A (0.40) | SIGMAR1CYP3A4TSHRCHRM5CHRM3 | |
| SCHEMBL6516176 | 0.76 | CYP1A2 (0.37) | SIGMAR1CYP3A4TSHRCHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104860924-A | Melanocortin receptor modulators, process for preparing same and use there in human medicine and cosmetics | GALDERMA RES & DEV | 2015-08-26 | — | — | CN | disclosed |
| CN-102203082-B | Melanocortin receptor modulators, processes for preparing them and their use in human medicine and cosmetics | GALDERMA RES & DEV | 2015-04-29 | — | — | CN | disclosed |
| US-8877968-B2 | Melanocortin receptor modulators, process for preparing them and use there in human medicine and cosmetics | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2014-11-04 | — | — | US | disclosed |
| EP-2352728-B1 | MELANOCORTIN RECEPTOR MODULATORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND COSMETICS | GALDERMA RES & DEV (FR) | 2014-05-21 | — | — | EP | disclosed |
| US-20110275657-A1 | MELANOCORTIN RECEPTOR MODULATORS, PROCESS FOR PREPARING THEM AND USE THERE IN HUMAN MEDICINE AND COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-11-10 | — | — | US | disclosed |
| CN-102203082-A | Melanocortin receptor modulators, processes for preparing them and their use in human medicine and cosmetics | GALDERMA RES & DEV | 2011-09-28 | — | — | CN | disclosed |
| EP-2352728-A1 | MELANOCORTIN RECEPTOR MODULATORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND COSMETICS | Galderma Research & Development (FR) | 2011-08-10 | — | — | EP | disclosed |
| WO-2010052255-A1 | MELANOCORTIN RECEPTOR MODULATORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275657-A1 | MELANOCORTIN RECEPTOR MODULATORS, PROCESS FOR PREPARING THEM AND USE THERE IN HUMAN MEDICINE AND COSMETICS | MC1R, MC5R, MC3R | SIGMAR1 782/4885CYP3A4 1637/4885TSHR 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.