Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312831 | 0.90 | PDE7A (0.47) | PDE7AKMT2AMEN1ALDH1A1BRCA1 | |
| SCHEMBL1311943 | 0.90 | PDE7A (0.53) | PDE7AKMT2AMEN1MGAT2ALDH1A1 | |
| SCHEMBL1310306 | 0.76 | MGAT2 (0.45) | PDE7AKMT2AMEN1MGAT2ALDH1A1 | |
| SCHEMBL12117474 | 0.74 | PDE7A (0.48) | PDE7AKMT2AMEN1MGAT2ALDH1A1 | |
| SCHEMBL12117475 | 0.72 | PDE7A (0.46) | PDE7AKMT2AMEN1MGAT2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1313492 | 0.71 | PDE7A (0.45) | PDE7AKMT2AMEN1MGAT2ALDH1A1 | |
| SCHEMBL12117149 | 0.66 | MGAT2 (0.62) | PDE7AMGAT2ALDH1A1MAPTLMNA | |
| SCHEMBL1311942 | 0.66 | MGAT2 (0.55) | PDE7AKMT2AMEN1MGAT2ALDH1A1 | |
| SCHEMBL1312830 | 0.65 | MGAT2 (0.47) | PDE7AKMT2AMEN1MGAT2ALDH1A1 | |
| SCHEMBL1310572 | 0.65 | MGAT2 (0.75) | PDE7AMGAT2ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2398800-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES | MSD K.K. (JP) | 2011-12-28 | — | — | EP | disclosed |
| US-20110275647-A1 | PYRIMIDIN-4-(3H)-ONE DERIVATIVES | MSD K.K. (JP) | 2011-11-10 | — | — | US | disclosed |
| WO-2010095767-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275647-A1 | PYRIMIDIN-4-(3H)-ONE DERIVATIVES | ABL1, JAK2, JAK1 | PDE7A 1606/4885KMT2A 2014/4885MEN1 1179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.