Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAT2 | Q10469 | 5/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1311942 | 0.93 | MGAT2 (0.55) | MGAT2TGM2PDE7ASMN1; SMN2P2RX3 | |
| SCHEMBL1310306 | 0.91 | MGAT2 (0.45) | MGAT2TGM2PDE7ATHRBSMN1; SMN2 | |
| SCHEMBL3301786 | 0.88 | MGAT2 (0.49) | MGAT2TGM2SMN1; SMN2P2RX3KMT2A | |
| SCHEMBL16005975 | 0.84 | MGAT2 (0.64) | MGAT2TGM2P2RX3MAPTPDE10A | |
| SCHEMBL3296988 | 0.80 | PARP1 (0.48) | MGAT2TGM2SMN1; SMN2P2RX3KMT2A | |
| SCHEMBL3303490 | 0.79 | PARP1 (0.41) | MGAT2TGM2P2RX3MAPTMAPK1 | |
| SCHEMBL3298037 | 0.76 | MGAT2 (0.43) | MGAT2PDE7ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3297765 | 0.76 | PRLHR (0.47) | MGAT2SMN1; SMN2P2RX3ALDH1A1LMNA | |
| SCHEMBL13329615 | 0.76 | PARP1 (0.40) | MGAT2TGM2P2RX3MAPTMAPK1 | |
| SCHEMBL3303209 | 0.75 | TAS1R3 (0.48) | MGAT2PDE7ASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232282-B2 | Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-07-31 | — | — | US | disclosed |
| EP-2398800-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES | MSD K.K. (JP) | 2011-12-28 | — | — | EP | disclosed |
| US-20110275647-A1 | PYRIMIDIN-4-(3H)-ONE DERIVATIVES | MSD K.K. (JP) | 2011-11-10 | — | — | US | disclosed |
| US-20110275647-A1 | PYRIMIDIN-4-(3H)-ONE DERIVATIVES | MSD K.K. (JP) | 2011-11-10 | — | — | US | disclosed |
| WO-2010095767-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-08-26 | — | — | WO | disclosed |
| US-20100093771-A1 | Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-04-15 | — | — | US | disclosed |
| EP-2078719-A1 | COMPOUND HAVING BICYCLIC PYRIMIDINE STRUCTURE AND PHARMACEUTICAL COMPOSITION COMPRISING THE COMPOUND | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2009-07-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093771-A1 | Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same | GART, MGAT2, MGAT1 | MGAT2 2/4885TGM2 1824/4885PDE7A 1079/4885 |
| US-20110275647-A1 | PYRIMIDIN-4-(3H)-ONE DERIVATIVES | ABL1, JAK2, JAK1 | MGAT2 4111/4885TGM2 4434/4885PDE7A 1606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.