Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12780 | 1.00 | KDM4E (0.41) | KDM4EHRH3MAOBGAASMN1; SMN2 | |
| SCHEMBL12390 | 1.00 | KDM4E (0.41) | KDM4EHRH3MAOBGAASMN1; SMN2 | |
| SCHEMBL11932 | 0.90 | MCHR1 (0.39) | KDM4EHRH3LMNAHPGDPOLB | |
| SCHEMBL12449690 | 0.90 | MCHR1 (0.39) | KDM4EHRH3LMNAHPGDPOLB | |
| SCHEMBL12950 | 0.84 | KDM4E (0.47) | KDM4EHRH3MAOBGAASMN1; SMN2 | |
| SCHEMBL12449662 | 0.84 | KDM4E (0.47) | KDM4EHRH3MAOBGAASMN1; SMN2 | |
| SCHEMBL18082890 | 0.84 | GBA1 (0.37) | KDM4ELMNA | |
| SCHEMBL12827 | 0.83 | ACHE (0.43) | KDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL12449646 | 0.83 | ACHE (0.43) | KDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL25854024 | 0.83 | ACHE (0.43) | KDM4ESMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |