Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.38 |
| ▸ | OGA | O60502 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13766310 | 0.82 | MAPT (0.39) | MAPTPKMCHEK1CHEK2TAS1R3 | |
| SCHEMBL12930960 | 0.80 | MAPT (0.46) | MAPTPKMALDH1A1LMNAHSD17B10 | |
| SCHEMBL852590 | 0.80 | MAPT (0.46) | MAPTPKMALDH1A1LMNAHSD17B10 | |
| SCHEMBL852591 | 0.80 | MAPT (0.46) | MAPTPKMALDH1A1LMNAHSD17B10 | |
| SCHEMBL13762278 | 0.79 | CHEK1 (0.39) | MAPTPKMCHEK1CHEK2ALDH1A1 | |
| SCHEMBL5656187 | 0.75 | PSEN1 (0.55) | ALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL14539583 | 0.75 | PSEN1 (0.51) | ALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL17469082 | 0.74 | CYP2C9 (0.35) | MAPTALDH1A1TAS1R3TAS1R1CYP2C9 | |
| SCHEMBL5658089 | 0.74 | PSEN1 (0.50) | ALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL5658093 | 0.74 | PSEN1 (0.50) | ALDH1A1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |