Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13766310 | 0.81 | MAPT (0.39) | CHEK1CHEK2MAPTPKMCA12 | |
| SCHEMBL13110287 | 0.79 | MAPT (0.38) | CHEK1CHEK2MAPTPKMALDH1A1 | |
| SCHEMBL852591 | 0.79 | MAPT (0.46) | MAPTPKMALDH1A1CA12CA1 | |
| SCHEMBL12930960 | 0.79 | MAPT (0.46) | MAPTPKMALDH1A1CA12CA1 | |
| SCHEMBL852590 | 0.79 | MAPT (0.46) | MAPTPKMALDH1A1CA12CA1 | |
| SCHEMBL8260643 | 0.76 | TAS1R3 (0.42) | MAPTMEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL13401297 | 0.75 | — | — | |
| SCHEMBL23419884 | 0.73 | MAPT (0.42) | CHEK1CHEK2MAPTPKMALDH1A1 | |
| SCHEMBL19063724 | 0.73 | MAPT (0.42) | MAPTPKMCA12CA1CA2 | |
| SCHEMBL23768677 | 0.73 | MAPT (0.42) | CHEK1CHEK2MAPTPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557110-B2 | MAPKAP-K2; inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth; 5-[(trans-4-aminocyclohexyl)amino]-3-fluoro-6-methyl(pyrazolo[1,5-a]pyri- midin-7-yl)}(4-iodophenyl)amine | TEIJIN PHARMA LIMITED (JP) | 2009-07-07 | — | — | US | disclosed |