Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30837088 | 1.00 | NR1H2 (0.48) | NR1H2USP30USP2SMN1; SMN2PDE4B | |
| Acetic Acid SCHEMBL3450215 | 0.96 | NR1H2 (0.44) | NR1H2USP30USP2SMN1; SMN2PDE4B | |
| SCHEMBL26906071 | 0.88 | NR1H2 (0.55) | NR1H2USP30USP2SMN1; SMN2PDE4B | |
| SCHEMBL21216437 | 0.88 | NR1H2 (0.55) | NR1H2USP30USP2SMN1; SMN2PDE4B | |
| SCHEMBL29827071 | 0.88 | NR1H2 (0.55) | NR1H2USP30USP2SMN1; SMN2PDE4B | |
| SCHEMBL14801400 | 0.88 | NR1H2 (0.55) | NR1H2USP30USP2SMN1; SMN2PDE4B | |
| SCHEMBL29826963 | 0.88 | NR1H2 (0.55) | NR1H2USP30USP2SMN1; SMN2PDE4B | |
| SCHEMBL2346218 | 0.87 | HPGD (0.43) | NR1H2USP2SMN1; SMN2PDE4BMEN1 | |
| SCHEMBL8197412 | 0.87 | HPGD (0.43) | NR1H2USP2SMN1; SMN2PDE4BMEN1 | |
| SCHEMBL7387261 | 0.87 | HPGD (0.43) | NR1H2USP2SMN1; SMN2PDE4BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |