SCHEMBL13110644

SCHEMBL13110644

C[Si](C)(C)C[Si](C)(CCCOc1ccc(C(=O)Oc2ccc(OC(F)(F)F)cc2)cc1)O[Si](C)(C)C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.43
NPC1 O15118 4/20 0.43
CYP1A2 P05177 2/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2C19 P33261 2/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
MAPT P10636 4/20 0.42
NFKB1 P19838 3/20 0.42
NFKB2 Q00653 3/20 0.42
RELA Q04206 3/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
KMT2A Q03164 2/20 0.42
EPHX2 P34913 3/20 0.41
PRSS1 P07477 1/20 0.41
ACR P10323 1/20 0.41
TSHR P16473 1/20 0.39
TDP1 Q9NUW8 1/20 0.37
POLB P06746 1/20 0.37
HDAC3 O15379 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13110642 0.89 KMT2A (0.46) LMNANPC1CYP1A2CYP2C9CYP2C19
SCHEMBL13110635 0.89 LMNA (0.45) LMNANPC1CYP1A2CYP2C9CYP2C19
SCHEMBL13610328 0.86 LMNA (0.46) LMNANPC1CYP1A2CYP2C9CYP2C19
SCHEMBL13110630 0.85 HRH2 (0.40) CYP1A2CYP2C9CYP2C19CYP3A4CYP2D6
SCHEMBL13110638 0.85 LMNA (0.47) LMNANPC1CYP1A2CYP2C9CYP2C19
SCHEMBL13110643 0.81 LMNA (0.46) LMNANPC1CYP1A2CYP2C9CYP2C19
SCHEMBL13610331 0.79 LMNA (0.46) LMNANPC1CYP1A2CYP2C9CYP2C19
SCHEMBL13110627 0.77 LMNA (0.44) LMNANPC1CYP1A2CYP2C9CYP2C19
SCHEMBL14131711 0.75 NPC1 (0.67) LMNANPC1CYP1A2CYP2C9CYP2C19
SCHEMBL13610334 0.75 LMNA (0.48) LMNANPC1CYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7820071-B2 Light modulating material and light modulating method FUJIFILM CORPORATION (JP) 2010-10-26 US disclosed
US-20090297735-A1 LIGHT MODULATING MATERIAL AND LIGHT MODULATING METHOD FUJI-FILM CORPORATION (JP) 2009-12-03 US disclosed