Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12057037 | 1.00 | EPHX2 (0.47) | EPHX2HSD11B1HPGDP2RX7MAPK1 | |
| SCHEMBL3505997 | 1.00 | EPHX2 (0.47) | EPHX2HSD11B1HPGDP2RX7MAPK1 | |
| SCHEMBL3505996 | 1.00 | EPHX2 (0.47) | EPHX2HSD11B1HPGDP2RX7MAPK1 | |
| SCHEMBL12057025 | 1.00 | EPHX2 (0.47) | EPHX2HSD11B1HPGDP2RX7MAPK1 | |
| SCHEMBL3505999 | 1.00 | EPHX2 (0.47) | EPHX2HSD11B1HPGDP2RX7MAPK1 | |
| SCHEMBL13819451 | 1.00 | EPHX2 (0.47) | EPHX2HSD11B1HPGDP2RX7MAPK1 | |
| SCHEMBL12057023 | 1.00 | EPHX2 (0.47) | EPHX2HSD11B1HPGDP2RX7MAPK1 | |
| SCHEMBL12057047 | 0.85 | LMNA (0.47) | EPHX2HSD11B1SMN1; SMN2 | |
| SCHEMBL12057044 | 0.85 | SMN1; SMN2 (0.46) | EPHX2HSD11B1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12057042 | 0.85 | SMN1; SMN2 (0.42) | HSD11B1SMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431569-B2 | Inhibitors of janus kinases | MERCK SHARP & DOHME CORP. (US) | 2013-04-30 | — | — | US | disclosed |
| US-8431569-B2 | Inhibitors of janus kinases | MERCK SHARP & DOHME CORP. (US) | 2013-04-30 | — | — | US | disclosed |
| US-20100267709-A1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME LLC | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267709-A1 | INHIBITORS OF JANUS KINASES | JAK2, JAK3, JAK1 | EPHX2 4746/4885HSD11B1 2855/4885HPGD 2595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.