Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | VHL | P40337 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13140797 | 0.79 | POLB (0.35) | POLBALDH1A1 | |
| SCHEMBL19414066 | 0.77 | KMT2A (0.41) | KMT2AMEN1FAAHMAPK1TSHR | |
| SCHEMBL13565764 | 0.77 | KMT2A (0.40) | KMT2AMEN1FAAHMAPK1TSHR | |
| SCHEMBL23475900 | 0.76 | MEN1 (0.43) | KMT2AMEN1FAAHMAPK1TSHR | |
| SCHEMBL7725268 | 0.76 | MEN1 (0.43) | KMT2AMEN1FAAHMAPK1TSHR | |
| SCHEMBL13118701 | 0.74 | KMT2A (0.38) | KMT2AMEN1FAAHMAPK1POLB | |
| SCHEMBL7724917 | 0.73 | ALDH1A1 (0.50) | KMT2AMEN1FAAHMAPK1TSHR | |
| SCHEMBL12376692 | 0.72 | KMT2A (0.40) | KMT2AMEN1FAAHMAPK1POLB | |
| SCHEMBL24040862 | 0.72 | TSHR (0.39) | KMT2AMEN1FAAHMAPK1POLB | |
| SCHEMBL5909175 | 0.72 | MEN1 (0.52) | KMT2AMEN1FAAHMAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812008-B2 | 9-substituted tetracyclines | WYETH LLC (US) | 2010-10-12 | — | — | US | disclosed |