Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3122523 | 0.82 | CYP2C19 (0.48) | PTPN11ALDH1A1CYP1A2CYP3A4MAPT | |
| SCHEMBL18291025 | 0.79 | PTPN11 (0.64) | PTPN11ALDH1A1MAPTCYP2C19CYP17A1 | |
| SCHEMBL1312427 | 0.79 | FAAH (0.52) | PTPN11 | |
| SCHEMBL1312448 | 0.78 | CYP17A1 (0.50) | CYP17A1NAMPT | |
| SCHEMBL18387837 | 0.77 | CYP17A1 (0.52) | CYP17A1CA12CA1CA9PSMB8 | |
| SCHEMBL12330823 | 0.75 | EPHX2 (0.69) | ALDH1A1CYP2C9CYP17A1EPHX2CA12 | |
| SCHEMBL26081219 | 0.74 | PTPN11 (0.53) | PTPN11ALDH1A1CYP2C19CYP17A1CA12 | |
| SCHEMBL20784539 | 0.74 | CYP17A1 (0.54) | CYP17A1PSMB8NAMPT | |
| SCHEMBL7043137 | 0.74 | PTPN11 (0.59) | PTPN11ALDH1A1MAPTCYP2C19CYP17A1 | |
| SCHEMBL7431047 | 0.74 | PTPN11 (0.56) | PTPN11ALDH1A1MAPTCYP2C19CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION | 2011-11-10 | — | — | US | disclosed |
| WO-2010033701-A2 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | SPHK1, SPHK2, S1PR1 | PTPN11 2653/4885ALDH1A1 1495/4885CYP1A2 1792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.