Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.56 |
| ▸ | S1PR4 | O95977 | 8/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.50 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.50 |
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 6/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312295 | 1.00 | FAAH (0.56) | FAAHS1PR4S1PR1S1PR3S1PR2 | |
| SCHEMBL19692741 | 0.85 | HTT (0.43) | ACACB | |
| SCHEMBL19700902 | 0.80 | HTT (0.49) | ACACB | |
| SCHEMBL20270868 | 0.80 | HTT (0.49) | ACACB | |
| SCHEMBL5419586 | 0.79 | FAAH (0.53) | FAAHS1PR4S1PR1S1PR3S1PR2 | |
| SCHEMBL16249714 | 0.77 | FAAH (0.61) | FAAHS1PR4S1PR1S1PR3SPHK1 | |
| SCHEMBL19700693 | 0.76 | CNR1 (0.45) | ACACB | |
| SCHEMBL21378363 | 0.76 | CNR1 (0.45) | ACACB | |
| SCHEMBL5414575 | 0.75 | HAO1 (0.53) | FAAHS1PR4S1PR1S1PR3S1PR2 | |
| SCHEMBL21399858 | 0.75 | CNR1 (0.49) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION | 2011-11-10 | — | — | US | disclosed |
| WO-2010033701-A2 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | SPHK1, SPHK2, S1PR1 | FAAH 352/4885S1PR4 8/4885S1PR1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.