SCHEMBL1312475

SCHEMBL1312475

O=[C]c1c(Cl)ccc(Cl)c1Cl

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.36
CYP3A4 P08684 1/20 0.36
CES1 P23141 2/20 0.35
TDP1 Q9NUW8 2/20 0.34
NOTUM Q6P988 1/20 0.32
CYP2A6 P11509 1/20 0.32
AHR P35869 2/20 0.31
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL104540 0.82 CES1 (0.32) MAPK1CYP3A4CES1TDP1
SCHEMBL103590 0.82 MAPK1 (0.30) MAPK1TDP1
SCHEMBL7311392 0.80 CYP3A4 (0.52) MAPK1CYP3A4TDP1TSHR
SCHEMBL909850 0.80 LMNA (0.38) MAPK1CYP3A4CES1TSHR
SCHEMBL7303363 0.77 MAPT (0.41) MAPK1CYP3A4TDP1
SCHEMBL96213 0.74 CYP1A2 (0.43) CES1TDP1CYP2A6TSHR
SCHEMBL1312947 0.74 CYP3A4 (0.47) MAPK1CYP3A4TDP1AHRTSHR
SCHEMBL1115821 0.74 TDP1 (0.62) MAPK1TDP1TSHR
SCHEMBL10624786 0.74 MAPK1 (0.31) MAPK1TDP1
SCHEMBL18244854 0.72 CYP3A4 (0.36) MAPK1CYP3A4CES1TDP1NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9234087-B2 Preparation for initiating radical reactions UNITED INITIATORS GMBH & CO. KG (DE) 2016-01-12 US claimed
EP-2288652-B1 PREPARATION FOR INITIATING RADICAL REACTIONS UNITED INITIATORS GMBH & CO KG (DE) 2012-09-19 EP claimed
EP-2130858-B1 Preparations to initiate radical reactions UNITED INITIATORS GMBH & CO KG (DE) 2012-07-25 EP claimed
US-20110272628-A1 Preparation For Initiating Radical Reactions UNITED INITIATORS GMBH (DE) 2011-11-10 US claimed
EP-2288652-A1 PREPARATION FOR INITIATING RADICAL REACTIONS United Initiators GmbH & Co. KG (DE) 2011-03-02 EP claimed
WO-2009146916-A1 PREPARATION FOR INITIATING RADICAL REACTIONS UNITED INITIATORS GMBH & CO. KG (DE) 2009-12-10 WO claimed
EP-2130858-A1 Preparations to initiate radical reactions Degussa Initiators GmbH & Co. KG (DE) 2009-12-09 EP claimed
EP-0827507-B1 PROTEASE INHIBITING SUCCINIC ACID DERIVATIVES BOEHRINGER INGELHEIM CA LTD (CA) 1999-06-16 EP claimed
EP-0827507-A1 PROTEASE INHIBITING SUCCINIC ACID DERIVATIVES BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 1998-03-11 EP claimed
WO-1996031527-A1 PROTEASE INHIBITING SUCCINIC ACID DERIVATIVES BOEHRINGER INGELHEIM (CANADA) LTD./BOEHRINGER INGELHEIM (CANADA) LTÉE. (CA) 1996-10-10 WO claimed
US-5545640-A VIRICIDES, HIV; AIDS BIO-MEGA/BOEHRINGER INGELEHEIM RESEARCH INC. (CA) 1996-08-13 US claimed
US-4868241-A POLYVINYL ALCOHOL MODIFIED WITH BENZOIC ACID DERIVATIVE AMERICAN CYANAMID COMPANY (US) 1989-09-19 US claimed
EP-0231922-A2 Electron beam and X-ray resists AMERICAN CYANAMID COMPANY (US) 1987-08-12 EP claimed
US-9234087-B2 Preparation for initiating radical reactions UNITED INITIATORS GMBH & CO. KG (DE) 2016-01-12 US disclosed
EP-2288652-B1 PREPARATION FOR INITIATING RADICAL REACTIONS UNITED INITIATORS GMBH & CO KG (DE) 2012-09-19 EP disclosed
EP-2130858-B1 Preparations to initiate radical reactions UNITED INITIATORS GMBH & CO KG (DE) 2012-07-25 EP disclosed
WO-1996031527-A1 PROTEASE INHIBITING SUCCINIC ACID DERIVATIVES BOEHRINGER INGELHEIM (CANADA) LTD./BOEHRINGER INGELHEIM (CANADA) LTÉE. (CA) 1996-10-10 WO disclosed
US-5545640-A VIRICIDES, HIV; AIDS BIO-MEGA/BOEHRINGER INGELEHEIM RESEARCH INC. (CA) 1996-08-13 US disclosed
US-4868241-A POLYVINYL ALCOHOL MODIFIED WITH BENZOIC ACID DERIVATIVE AMERICAN CYANAMID COMPANY (US) 1989-09-19 US disclosed
EP-0231922-A2 Electron beam and X-ray resists AMERICAN CYANAMID COMPANY (US) 1987-08-12 EP disclosed