Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 9/20 | 0.57 |
| ▸ | AKT1 | P31749 | 14/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459645 | 0.86 | AKT1 (0.60) | PIK3CBAKT1RAF1BRAF | |
| SCHEMBL3459651 | 0.79 | AKT1 (0.56) | PIK3CBAKT1RAF1BRAF | |
| SCHEMBL12946806 | 0.77 | MEN1 (0.40) | — | |
| SCHEMBL13126277 | 0.71 | KMT2A (0.40) | — | |
| SCHEMBL28736434 | 0.69 | PIK3CB (0.67) | PIK3CBPIK3CDPIK3CAHRH4 | |
| SCHEMBL13126279 | 0.68 | CA1 (0.36) | — | |
| SCHEMBL3118285 | 0.67 | AKT1 (0.55) | PIK3CBAKT1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL27880182 | 0.67 | AKT1 (0.79) | PIK3CBAKT1PIK3CDPIK3CACYP3A4 | |
| SCHEMBL12946823 | 0.67 | MEN1 (0.58) | CYP3A4 | |
| SCHEMBL13125750 | 0.65 | KMT2A (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |