Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.56 |
| ▸ | RAF1 | P04049 | 11/20 | 0.53 |
| ▸ | BRAF | P15056 | 11/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459645 | 0.93 | AKT1 (0.60) | AKT1RAF1BRAFPIK3CBGAA | |
| SCHEMBL3459310 | 0.80 | GRK2 (0.49) | GAAKDM4ELMNAMAPTKMT2A | |
| SCHEMBL13126223 | 0.79 | PIK3CB (0.57) | AKT1RAF1BRAFPIK3CB | |
| SCHEMBL967955 | 0.77 | GRK2 (0.45) | GAAKDM4ELMNAMAPTKMT2A | |
| SCHEMBL965838 | 0.77 | AKT1 (0.46) | AKT1RAF1BRAFGAAKDM4E | |
| SCHEMBL10327354 | 0.75 | AKT1 (0.52) | AKT1RAF1BRAFGAALMNA | |
| SCHEMBL28755083 | 0.72 | AKT1 (0.55) | AKT1RAF1BRAFPIK3CBLMNA | |
| SCHEMBL29671886 | 0.72 | AKT1 (0.55) | AKT1RAF1BRAFPIK3CBLMNA | |
| SCHEMBL3117525 | 0.72 | EPHX2 (0.63) | AKT1RAF1BRAFLMNAKMT2A | |
| SCHEMBL3459306 | 0.72 | KDR (0.51) | GAAKDM4ELMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |