Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 4/20 | 0.60 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.60 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.52 |
| ▸ | SPHK2 | Q9NRA0 | 14/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 11/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19968731 | 0.76 | S1PR1 (0.75) | S1PR1S1PR5S1PR4NPC1ALDH1A1 | |
| SCHEMBL4744048 | 0.75 | S1PR1 (1.00) | S1PR1S1PR5S1PR4S1PR3 | |
| SCHEMBL1312648 | 0.74 | S1PR1 (0.67) | S1PR1S1PR5S1PR4S1PR3 | |
| SCHEMBL13416798 | 0.73 | NPC1 (1.00) | S1PR1S1PR5S1PR4NPC1ALDH1A1 | |
| SCHEMBL1312932 | 0.73 | S1PR1 (0.75) | S1PR1S1PR5S1PR4NPC1ALDH1A1 | |
| SCHEMBL13271363 | 0.71 | S1PR1 (1.00) | S1PR1S1PR5S1PR4S1PR3 | |
| SCHEMBL4742220 | 0.70 | S1PR1 (0.70) | S1PR1S1PR5S1PR4NPC1ALDH1A1 | |
| SCHEMBL13417167 | 0.69 | NPC1 (0.90) | S1PR1S1PR5NPC1ALDH1A1MAPT | |
| SCHEMBL1312187 | 0.68 | SPHK1 (0.77) | SPHK1 | |
| SCHEMBL13271364 | 0.68 | S1PR1 (1.00) | S1PR1S1PR5S1PR4S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | SPHK1, SPHK2, S1PR1 | S1PR1 3/4885S1PR5 6/4885S1PR4 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.