Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 4/20 | 0.75 |
| ▸ | NPC1 | O15118 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | MAPT | P10636 | 2/20 | 0.75 |
| ▸ | RAB9A | P51151 | 2/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.75 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.75 |
| ▸ | RELA | Q04206 | 1/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.75 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.57 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | SPHK1 | Q9NYA1 | 12/20 | 0.52 |
| ▸ | SPHK2 | Q9NRA0 | 11/20 | 0.52 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312371 | 0.91 | S1PR1 (0.62) | S1PR1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL19968731 | 0.86 | S1PR1 (0.75) | S1PR1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL13416798 | 0.86 | NPC1 (1.00) | S1PR1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL26887351 | 0.85 | S1PR1 (0.56) | S1PR1NPC1ALDH1A1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL26691045 | 0.84 | S1PR1 (0.55) | S1PR1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL4742220 | 0.82 | S1PR1 (0.70) | S1PR1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL13417167 | 0.81 | NPC1 (0.90) | S1PR1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL28239842 | 0.80 | NR1H4 (0.70) | S1PR1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL28863179 | 0.80 | NR1H4 (0.65) | S1PR1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL1312871 | 0.80 | SPHK1 (0.62) | S1PR1NPC1ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION | 2011-11-10 | — | — | US | disclosed |
| WO-2010033701-A2 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | SPHK1, SPHK2, S1PR1 | S1PR1 3/4885NPC1 137/4885ALDH1A1 1495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.