TAS1R3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL95611	0.63	14/20
SCHEMBL200816	0.63	9/20
SCHEMBL245758	0.54	9/20
SCHEMBL165896	0.54	9/20
SCHEMBL178910	0.53	9/20
SCHEMBL108094	0.52	9/20
SCHEMBL139991	0.52	9/20
SCHEMBL108186	0.47	8/20
SCHEMBL201947	0.69	7/20
Siduron (SCHEMBL66323)	0.66	7/20
SCHEMBL201362	0.65	7/20
SCHEMBL162688	0.62	7/20
3,6 Dichloromethoxybenzoic Acid (SCHEMBL18336)	0.51	7/20
SCHEMBL203603	0.67	6/20
SCHEMBL203604	0.67	6/20
SCHEMBL40230	0.65	6/20
SCHEMBL44779	0.65	6/20
SCHEMBL44802	0.65	6/20
SCHEMBL44803	0.65	6/20
SCHEMBL201891	0.63	6/20

Clinical trials — most relevant to TAS1R3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Trial of Efficacy and Safety of Raphamin in the Treatment of Coronavirus Disease 2019 in Outpatients	PHASE3	COMPLETED
Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes	PHASE2	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries	nan	COMPLETED
Fructose and Glucose and TAS1R2 in Type 1 Diabetes	nan	COMPLETED
Sensory Study: Taste and Tongue Biology	nan	COMPLETED
Vegetables Intake and Polymorphism TAS2R38 Gene by Healthy Adults	nan	COMPLETED
Ibuprofen Inhibits Human Sweet Taste	nan	COMPLETED
Allele-specific Expression of a Bitter Taste Receptor	nan	COMPLETED
NUTRACORE, Glycaemic Index and Appetite	nan	COMPLETED
The Effect of Lactisole on the Responses to Glucose Solution	nan	UNKNOWN
Gustin Gene Polymorphism and 6-n-propylthiouracil (PROP) Taste	nan	COMPLETED
Sucralose and Lactisole Additions to OGTT in Humans	nan	COMPLETED
Flavour Programming: Fruit and Vegetable Palatability	nan	COMPLETED
Study of Taste Deficits	nan	COMPLETED
Sensitive Periods in Early Flavor Learning	nan	COMPLETED
A Study of the Function of Hormones Present In Taste Buds	nan	COMPLETED
Bitter Taste Receptors in Oropharynx Cancer	nan	UNKNOWN
Taste Preferences for Nutritive and Non Nutritive Sweeteners Among Children and Adults	nan	COMPLETED
Factors Affecting Salt Intake in Young Adults	nan	UNKNOWN
Genetic Variability in Taste Perception	nan	COMPLETED
Astringency and Oral Health	nan	COMPLETED
CD36 and Human Fat Taste Perception	nan	COMPLETED
Taste Perception and Chronic Disease Risk	nan	COMPLETED
Impacts of Sugar-Sweetened Beverage on Body Weight	nan	COMPLETED
Adaptation Strategies for Coping With the Impact of Sensory Alterations on Eating Behavior in Children With Cancer: A Qualitative Study From the Perspective of Children and Parents	nan	NOT_YET_RECRUITING
The Effects of GLP-1 Receptor Agonists on Chemosensory Function and Ingestive Behavior	nan	COMPLETED
The Effect of Artificial Sweeteners on Blood Glucose Response	nan	WITHDRAWN

Related proteins — ESM-2 sequence neighbours (a TAS1R3 binder may also engage these)

Protein	Name	Similarity
Q717C1	—	1.000	Q717C1 →
Q717C2	—	1.000	Q717C2 →
Q49HH9	—	1.000	Q49HH9 →
Q49KI5	—	1.000	Q49KI5 →
Q923K1	—	1.000	Q923K1 →
Q925D8	—	0.995	Q925D8 →
TAS1R1	Taste receptor type 1 member 1 (G protein-cou	0.992	landscape →
Q99PG6	—	0.988	Q99PG6 →
Q9Z0R8	—	0.986	Q9Z0R8 →
Q49HI0	—	0.979	Q49HI0 →
A3QNZ8	—	0.977	A3QNZ8 →
A3QP00	—	0.977	A3QP00 →
A3QP09	—	0.976	A3QP09 →
A3QNZ9	—	0.975	A3QNZ9 →
A3QP07	—	0.975	A3QP07 →
TAS1R2	Taste receptor type 1 member 2	0.975	landscape →
Q13444	—	0.974	Q13444 →
A3QP08	—	0.972	A3QP08 →
Q0V8J4	—	0.972	Q0V8J4 →
Q6P5W5	—	0.971	Q6P5W5 →
A3QP01	—	0.971	A3QP01 →
ITGA2B	Integrin alpha-IIb	0.971	landscape →
A7MBM2	—	0.971	A7MBM2 →
Q925I4	—	0.971	Q925I4 →
Q9D856	—	0.970	Q9D856 →
P51839	—	0.970	P51839 →
Q643R3	—	0.969	Q643R3 →
Q5T3U5	—	0.969	Q5T3U5 →
Q7TNJ2	—	0.969	Q7TNJ2 →
Q8BNJ2	—	0.969	Q8BNJ2 →