⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1313714 | 0.82 | — | — | |
| SCHEMBL7922289 | 0.81 | MMP2 (0.61) | — | |
| SCHEMBL1313332 | 0.80 | — | — | |
| SCHEMBL1314537 | 0.80 | — | — | |
| SCHEMBL1316298 | 0.79 | — | — | |
| SCHEMBL1314688 | 0.79 | — | — | |
| SCHEMBL1314853 | 0.79 | — | — | |
| SCHEMBL1314090 | 0.78 | — | — | |
| SCHEMBL1314317 | 0.78 | — | — | |
| SCHEMBL1314670 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785489-B2 | Heteroaryl substituted indole compounds useful as MMP-13 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-22 | — | — | US | disclosed |
| US-20110275631-A1 | Heteroaryl Substituted Indole Compounds Useful as MMP-13 Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-10 | — | — | US | disclosed |