Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.58 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1313156 | 0.89 | PIK3CD (0.63) | PIK3CD | |
| SCHEMBL1313281 | 0.86 | PIK3CD (0.56) | PIK3CDPTK2JAK2NTRK1TYK2 | |
| SCHEMBL6987132 | 0.81 | PIK3CD (0.54) | PIK3CDEPAS1 | |
| SCHEMBL1313527 | 0.80 | PIK3CD (0.49) | PIK3CDEPAS1 | |
| SCHEMBL6745119 | 0.78 | PIK3CD (0.62) | PIK3CD | |
| SCHEMBL6989437 | 0.77 | PIK3CD (0.58) | PIK3CD | |
| SCHEMBL2438488 | 0.76 | PIK3CD (0.56) | PIK3CD | |
| SCHEMBL788676 | 0.75 | PIK3CD (0.58) | PIK3CD | |
| SCHEMBL15471385 | 0.74 | PIK3CD (0.98) | PIK3CD | |
| SCHEMBL4174263 | 0.73 | PIK3CD (0.53) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139882-B1 | 3- SUBSTITUTED QUINOLINE OR QUINOXALINE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS | AMGEN INC (US) | 2013-12-25 | — | — | EP | disclosed |
| US-8329910-B2 | Quinolines for the treatment of PI3K-δ mediated diseases | AMGEN INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-8329910-B2 | Quinolines for the treatment of PI3K-δ mediated diseases | AMGEN INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-8329910-B2 | Quinolines for the treatment of PI3K-δ mediated diseases | AMGEN INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-8183258-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183258-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183259-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183259-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183258-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-20110281897-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-11-17 | — | — | US | disclosed |
| US-20100179177-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-07-15 | — | — | US | disclosed |
| US-7705018-B2 | Substituted quinolines and their uses in treatment of inflammatory and related conditions | AMGEN INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-7705018-B2 | Substituted quinolines and their uses in treatment of inflammatory and related conditions | AMGEN INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-7705018-B2 | Substituted quinolines and their uses in treatment of inflammatory and related conditions | AMGEN INC. (US) | 2010-04-27 | — | — | US | disclosed |
| EP-2139882-A1 | 3- SUBSTITUTED QUINOLINE OR QUINOXALINE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE ( PI3K) INHIBITORS | Amgen Inc. (US) | 2010-01-06 | — | — | EP | disclosed |
| US-20090023761-A1 | Heterocyclic compounds and their uses | AMGEN INC. | 2009-01-22 | — | — | US | disclosed |
| US-20090023761-A1 | Heterocyclic compounds and their uses | AMGEN INC. | 2009-01-22 | — | — | US | disclosed |
| US-20090023761-A1 | Heterocyclic compounds and their uses | AMGEN INC. | 2009-01-22 | — | — | US | disclosed |
| WO-2008118455-A1 | δ3- SUBSTITUTED QUINOLINE OR QUINOXALINE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE ( PI3K) INHIBITORS | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |
| WO-2008118455-A1 | δ3- SUBSTITUTED QUINOLINE OR QUINOXALINE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE ( PI3K) INHIBITORS | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023761-A1 | Heterocyclic compounds and their uses | MCL1, BCL9, MALT1 | PIK3CD 16/4885EPAS1 1113/4885PTK2 426/4885 |
| US-20100179177-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, BCL9, MALT1 | PIK3CD 16/4885EPAS1 1113/4885PTK2 426/4885 |
| US-20110281897-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, BCL9, MALT1 | PIK3CD 15/4885EPAS1 1131/4885PTK2 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.