Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312808 | 0.82 | PIK3CD (0.48) | PIK3CDL3MBTL1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL1313527 | 0.81 | PIK3CD (0.49) | PIK3CDKDM4E | |
| SCHEMBL1313156 | 0.80 | PIK3CD (0.63) | PIK3CDL3MBTL1DRD4DRD3 | |
| SCHEMBL1313191 | 0.77 | PIK3CD (0.58) | PIK3CD | |
| SCHEMBL6745119 | 0.77 | PIK3CD (0.62) | PIK3CDL3MBTL1DRD4DRD3 | |
| SCHEMBL6990066 | 0.76 | PIK3CD (0.45) | PIK3CDL3MBTL1DRD4DRD3KDM4E | |
| SCHEMBL788676 | 0.76 | PIK3CD (0.58) | PIK3CD | |
| SCHEMBL1317455 | 0.75 | PIK3CD (0.44) | PIK3CDKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL15471385 | 0.74 | PIK3CD (0.98) | PIK3CDL3MBTL1DRD4DRD3GAA | |
| SCHEMBL1313281 | 0.74 | PIK3CD (0.56) | PIK3CDL3MBTL1DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183259-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2012-05-22 | — | — | US | disclosed |