Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 6/20 | 0.42 |
| ▸ | KARS1 | Q15046 | 5/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136120 | 0.91 | SYK (0.44) | SYKKARS1MAPTKDRJAK2 | |
| SCHEMBL13136040 | 0.90 | PTPRB (0.44) | PTPRBSYKKARS1KDRJAK2 | |
| SCHEMBL13136034 | 0.89 | PTPRB (0.53) | PTPRBSYKKARS1PTPN1KDR | |
| SCHEMBL13136044 | 0.88 | MAPT (0.48) | PTPRBSYKMAPTKMT2ANPSR1 | |
| SCHEMBL13136092 | 0.86 | PTPRB (0.50) | PTPRBSYKKARS1PTPN1JAK2 | |
| SCHEMBL13136115 | 0.86 | SYK (0.45) | SYKKARS1KDRJAK2 | |
| SCHEMBL13135987 | 0.81 | SYK (0.47) | SYKKARS1KDR | |
| SCHEMBL13136028 | 0.81 | SYK (0.47) | SYKKARS1KDR | |
| SCHEMBL13136042 | 0.80 | SYK (0.46) | SYKKARS1MAPTKDRJAK2 | |
| SCHEMBL13136132 | 0.79 | SYK (0.49) | SYKKARS1MAPTKDRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |