Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.45 |
| ▸ | KARS1 | Q15046 | 9/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136120 | 0.88 | SYK (0.44) | SYKKARS1JAK2KDRNPC1 | |
| SCHEMBL13136113 | 0.86 | PTPRB (0.42) | SYKKARS1JAK2KDR | |
| SCHEMBL13136205 | 0.84 | SYK (0.43) | SYKKARS1JAK2KDR | |
| SCHEMBL13136094 | 0.81 | KARS1 (0.46) | SYKKARS1KDRNPC1RAB9A | |
| SCHEMBL2865504 | 0.80 | KARS1 (0.52) | SYKKARS1JAK2KDRNPC1 | |
| SCHEMBL13136042 | 0.79 | SYK (0.46) | SYKKARS1JAK2KDRNPC1 | |
| SCHEMBL13136185 | 0.79 | KARS1 (0.47) | SYKKARS1JAK2KDRNPC1 | |
| SCHEMBL13136061 | 0.79 | KARS1 (0.54) | SYKKARS1JAK2KDRNPC1 | |
| SCHEMBL14390934 | 0.78 | SYK (0.46) | SYKKARS1JAK2KDRNPC1 | |
| SCHEMBL13136157 | 0.76 | SYK (0.45) | SYKKARS1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |