Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.45 |
| ▸ | KARS1 | Q15046 | 9/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.38 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.38 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136158 | 0.93 | SYK (0.46) | SYKKARS1KCNN1KCNN2KCNN3 | |
| SCHEMBL2872543 | 0.87 | KARS1 (0.50) | SYKKARS1KCNN1KCNN2KCNN3 | |
| SCHEMBL13136182 | 0.86 | SYK (0.46) | SYKKARS1KCNN1KCNN2KCNN3 | |
| SCHEMBL13136159 | 0.86 | SYK (0.51) | SYKKARS1KCNN1KCNN2KCNN3 | |
| SCHEMBL13136054 | 0.84 | KARS1 (0.50) | SYKKARS1KCNN1KCNN2KCNN3 | |
| SCHEMBL2859100 | 0.84 | KARS1 (0.52) | SYKKARS1KCNN1KCNN2KCNN3 | |
| SCHEMBL13136342 | 0.84 | SYK (0.47) | SYKKARS1KCNN1KCNN2KCNN3 | |
| SCHEMBL13136024 | 0.83 | KARS1 (0.51) | SYKKARS1KCNN1KCNN2KCNN3 | |
| SCHEMBL13136339 | 0.82 | SYK (0.46) | SYKKARS1KCNN1KCNN2KCNN3 | |
| SCHEMBL13136025 | 0.82 | KARS1 (0.50) | SYKKARS1KCNN1KCNN2KCNN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |