KARS1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL902600	1.00	20/20
SCHEMBL902071	0.72	20/20
SCHEMBL901824	1.00	18/20
SCHEMBL902162	1.00	18/20
SCHEMBL901742	1.00	17/20
SCHEMBL901799	1.00	17/20
SCHEMBL1704222	1.00	17/20
SCHEMBL902055	0.88	17/20
SCHEMBL901780	0.84	17/20
SCHEMBL901750	0.81	17/20
SCHEMBL901889	0.81	17/20
SCHEMBL901905	0.80	17/20
SCHEMBL1704214	0.77	17/20
SCHEMBL901852	0.77	17/20
SCHEMBL902170	0.77	17/20
SCHEMBL901789	0.75	17/20
SCHEMBL902386	0.75	17/20
SCHEMBL1704220	0.74	17/20
SCHEMBL901687	0.74	17/20
SCHEMBL902883	0.73	17/20

Clinical trials — most relevant to KARS1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study of KRN23 in Pediatric Patients With X-linked Hypophosphatemic Rickets/Osteomalacia	PHASE3	COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.	nan	UNKNOWN
Natural History Study of FDXR Mutation-related Mitochondriopathy	nan	COMPLETED
Study of a Candidate Gene Involved in Goldenhar Syndrome.	nan	COMPLETED
Study of Chediak-Higashi Syndrome	nan	RECRUITING
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress	nan	WITHDRAWN
Quantifying Disease Progression in LBSL	nan	UNKNOWN
Exploiting Epigenome Editing in Kabuki Syndrome: a New Route Towards Gene Therapy for Rare Genetic Disorders	nan	COMPLETED
Phenotype/Genotype Correlations in Neuromuscular Disorders	nan	COMPLETED
Diagnosis and Phenotype Characterisation Using Genomics in Patients With Inherited Bone Marrow Failure (IBMDx Study)	nan	RECRUITING
A Long-Term Study of Cholesterol Supplements for Smith-Lemli-Opitz Syndrome	nan	WITHDRAWN
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes	nan	RECRUITING
Combining Exome and Transcriptome Data to Unravel the Genetic Basis of the Lissencephalies	nan	UNKNOWN
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
The Classification and Cause of Leukodystrophies of Unknown Cause	nan	COMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Whole Genome Sequencing in the Neonatal Intensive Care Unit	nan	COMPLETED
Lysine Oxidation in Response to Arginine Supplementation	nan	COMPLETED
Genetics of Ehlers-Danlos Syndrome	nan	COMPLETED
Biomarker for Sanfilippo Type A-B-C-D Disease (BioSanfilippo)	nan	WITHDRAWN
Advancing Neurogenetic Diagnoses Through Long-Read Sequencing	nan	NOT_YET_RECRUITING
Natural History of the Leukodystrophies	nan	COMPLETED
Mapping Novel Disease Genes for Dilated Cardiomyopathy	nan	COMPLETED
Intermittent Fasting for Pancreatitis	nan	NOT_YET_RECRUITING
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Corpus Callosum Agenesis and Intellectual Disability	nan	COMPLETED
Clinical Study of Muenke Syndrome (FGFR3-Related Craniosynostosis)	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a KARS1 binder may also engage these)

Protein	Name	Similarity
Q99MN1	—	1.000	Q99MN1 →
Q5XIM7	—	1.000	Q5XIM7 →
Q9SSK1	—	1.000	Q9SSK1 →
O74407	—	0.999	O74407 →
Q9ZPI1	—	0.999	Q9ZPI1 →
Q43776	—	0.997	Q43776 →
Q75JQ1	—	0.997	Q75JQ1 →
A0A120HYZ1	—	0.994	A0A120HYZ1 →
P37879	—	0.994	P37879 →
Q22099	—	0.994	Q22099 →
Q9M084	—	0.993	Q9M084 →
Q6HCW9	—	0.992	Q6HCW9 →
A9NE58	—	0.992	A9NE58 →
P15180	—	0.992	P15180 →
Q6F2U9	—	0.991	Q6F2U9 →
Q554D9	—	0.991	Q554D9 →
A1KUN1	—	0.989	A1KUN1 →
A5W890	—	0.989	A5W890 →
O94242	—	0.989	O94242 →
P04802	—	0.989	P04802 →
Q9UUE6	—	0.989	Q9UUE6 →
Q55FI3	—	0.989	Q55FI3 →
Q817I8	—	0.989	Q817I8 →
P0A8N4	—	0.989	P0A8N4 →
A4XXQ6	—	0.989	A4XXQ6 →
Q64PM9	—	0.988	Q64PM9 →
B3H1E8	—	0.988	B3H1E8 →
Q83JU6	—	0.988	Q83JU6 →
Q3K1V5	—	0.988	Q3K1V5 →
B0URW9	—	0.988	B0URW9 →