Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.51 |
| ▸ | KARS1 | Q15046 | 9/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136271 | 0.93 | SYK (0.54) | SYKKARS1KDRMEN1NPC1 | |
| SCHEMBL13136164 | 0.88 | SYK (0.51) | SYKKARS1MAPT | |
| SCHEMBL2869810 | 0.87 | KARS1 (0.53) | SYKKARS1KDRMEN1NPC1 | |
| SCHEMBL13136179 | 0.87 | SYK (0.53) | SYKKARS1KDRMEN1NPC1 | |
| SCHEMBL2865358 | 0.86 | SYK (0.53) | SYKKARS1KDRNPC1SMN1; SMN2 | |
| SCHEMBL2866523 | 0.86 | SYK (0.51) | SYKKARS1KDR | |
| SCHEMBL2868941 | 0.86 | KARS1 (0.53) | SYKKARS1KDRMEN1NPC1 | |
| SCHEMBL13136168 | 0.85 | SYK (0.54) | SYKKARS1KDRNPC1SMN1; SMN2 | |
| SCHEMBL2868020 | 0.85 | KARS1 (0.56) | SYKKARS1KDR | |
| SCHEMBL13136069 | 0.85 | SYK (0.50) | SYKKARS1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |