Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.49 |
| ▸ | KARS1 | Q15046 | 8/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2862312 | 0.91 | SYK (0.52) | SYKKARS1KDR | |
| SCHEMBL13136173 | 0.87 | KARS1 (0.48) | SYKKARS1KDR | |
| SCHEMBL2869423 | 0.87 | KARS1 (0.49) | SYKKARS1KDR | |
| SCHEMBL2865498 | 0.87 | KARS1 (0.49) | SYKKARS1KDR | |
| SCHEMBL2871117 | 0.86 | KARS1 (0.49) | SYKKARS1 | |
| SCHEMBL13136241 | 0.86 | NPC1 (0.50) | SYKKARS1KDR | |
| SCHEMBL13136239 | 0.85 | KARS1 (0.54) | SYKKARS1KDR | |
| SCHEMBL13136288 | 0.85 | SYK (0.51) | SYKKARS1KDR | |
| SCHEMBL2863200 | 0.84 | SYK (0.48) | SYKKARS1KDR | |
| SCHEMBL2869931 | 0.84 | SYK (0.48) | SYKKARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |