Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.49 |
| ▸ | KARS1 | Q15046 | 9/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136187 | 0.91 | SYK (0.52) | SYKKARS1KDRJAK2 | |
| SCHEMBL13136027 | 0.86 | SYK (0.49) | SYKKARS1KDRJAK2 | |
| SCHEMBL2866521 | 0.84 | KARS1 (0.56) | SYKKARS1KDRJAK2 | |
| SCHEMBL13136188 | 0.83 | SYK (0.46) | SYKKARS1KDR | |
| SCHEMBL2865910 | 0.82 | KARS1 (0.58) | SYKKARS1KDRJAK2 | |
| SCHEMBL13136059 | 0.81 | SYK (0.48) | SYKKARS1KDRJAK2 | |
| SCHEMBL13136090 | 0.80 | KARS1 (0.56) | SYKKARS1KDRJAK2 | |
| SCHEMBL13136022 | 0.80 | KARS1 (0.57) | SYKKARS1KDRJAK2 | |
| SCHEMBL13136077 | 0.80 | KARS1 (0.51) | SYKKARS1KDRJAK2 | |
| SCHEMBL2868809 | 0.80 | KARS1 (0.51) | SYKKARS1KDRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |