Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 3/20 | 0.34 |
| ▸ | ACACA | Q13085 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136082 | 0.87 | KDR (0.46) | SYKKDRKARS1ACACB | |
| SCHEMBL13136087 | 0.86 | ACACB (0.44) | SYKKDRACACBACACA | |
| SCHEMBL2859100 | 0.82 | KARS1 (0.52) | SYKKDRKDM4EALDH1A1LMNA | |
| SCHEMBL13136605 | 0.82 | AKT3 (0.41) | SYKADORA2AKDM4EALDH1A1LMNA | |
| SCHEMBL13136237 | 0.81 | SYK (0.41) | SYKKDM4EALDH1A1LMNAKARS1 | |
| SCHEMBL2861389 | 0.81 | SYK (0.52) | SYKROCK2ROCK1KARS1ACACB | |
| SCHEMBL13136326 | 0.80 | SYK (0.46) | SYKKDRKARS1 | |
| SCHEMBL2863845 | 0.80 | KARS1 (0.42) | SYKKDM4EALDH1A1LMNAKARS1 | |
| SCHEMBL2869607 | 0.79 | MAP3K5 (0.42) | SYKKARS1ACACBACACA | |
| SCHEMBL13136324 | 0.78 | SYK (0.46) | SYKKDRKARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |