Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.43 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 3/20 | 0.33 |
| ▸ | ACACA | Q13085 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2869766 | 0.89 | SYK (0.42) | SYKKARS1 | |
| SCHEMBL2859100 | 0.84 | KARS1 (0.52) | SYKKARS1 | |
| SCHEMBL2861389 | 0.83 | SYK (0.52) | SYKKARS1ACACBACACA | |
| SCHEMBL13136237 | 0.83 | SYK (0.41) | SYKKARS1ACACBACACA | |
| SCHEMBL13136082 | 0.81 | KDR (0.46) | SYKKARS1ACACB | |
| SCHEMBL2863845 | 0.81 | KARS1 (0.42) | SYKKARS1 | |
| SCHEMBL13136598 | 0.81 | SYK (0.41) | SYKKARS1 | |
| SCHEMBL2869607 | 0.81 | MAP3K5 (0.42) | SYKKARS1ACACBACACA | |
| SCHEMBL13136326 | 0.80 | SYK (0.46) | SYKKARS1 | |
| SCHEMBL13136087 | 0.77 | ACACB (0.44) | SYKACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |