Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.45 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.45 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2865766 | 0.86 | KDR (0.59) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL13136547 | 0.85 | KARS1 (0.61) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL2227800 | 0.84 | KARS1 (0.58) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL2862806 | 0.84 | KDR (0.57) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL2862731 | 0.84 | KARS1 (0.55) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL13136178 | 0.84 | KARS1 (0.60) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL13136147 | 0.84 | KARS1 (0.55) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL2859905 | 0.84 | KARS1 (0.55) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL2228189 | 0.84 | KARS1 (0.55) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL2865910 | 0.84 | KARS1 (0.58) | KARS1KDRSYKMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |